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3 MEMANTINE THERAPY FOR AD 3 1 Basic information about AD AD is the most prevalent type of dementia and one of the most common chronic diseases among the elderly, with chronic, progressive, and irreversible characteristics, affecting almost 50 million elderly individuals worldwide 13, 14 Studies suggest that 152 million people will have AD by 2050, with approximately one in every 64 people --- nature com articles nrd1311--- thelancet com article S1474-4422(21)00369-0 fulltextAre memantine and donepezil effective in the treatment of AD? Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial - The Lancet Neurology Articles | Volume 21, ISSUE 1, P31-41, January 2022 jamanetwork com journals jamaneurology fullarticle 1107815--- tandfonline com doi full 10 2147 cia s6666When was memantine approved? A 12-week multicenter European trial 6 of memantine 10 mg d was conducted in 166 nursing home residents with severe dementia, including both Alzheimer type and vascular dementias, diagnosed by Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteria 18 (mean baseline MMSE of 6 3) Significant benefit of memantine vs onlinelibrary wiley com doi full 10 1002 brb3 1831Vascular dementia may respond, at least to some extent, to these drugs (T Erkinjuntti and colleagues, Lancet 2002; 359: 1283–90) In 2002, the Committee of Proprietary Medicinal Products recommended that memantine—a drug that acts on the glutamatergic system rather than the cholinergic system—be approved by the European Commission for the touchneurology com the-availability-of-antidementia-drugs-in-europeIs memantine safe? Jun 4, 2011 · Memantine , the most recent drug approved for the treatment of Alzheimer’s disease, has not yet been made subject to a reimbursement decision in Bulgaria, Italy, Latvia, Malta, Norway or Poland Similarly, most health trusts in the UK do not cover memantine under the National Health Service As can be seen from Table 1, with the exception of Bulgaria, Latvia and Malta, one or more AchIs are reimbursed in all the European countries covered by the Alzheimer Europe survey, even if there may be slight variations as to which of the medicines are available and reimbursed Memantine, the most recent drug approved for the treatment of May 18, 2021 · Abstract The treatment of bipolar depression is hampered by the inadequate efficacy of antidepressants, moderate effect of mood stabilizers, and the side effects of some second-generation antipsychotics There is limited evidence to date regarding the antidepressant effects of memantine in bipolar depression Sep 28, 2009 · Citation 13, Citation 14 In 2003, memantine was approved for the treatment of moderate to severe AD in the US and in Europe Approval for memantine permitted it to be used alone or in combination with ChEI While it is currently in use for the therapy of moderate to severe AD, other diseases and disorders are potential targets for therapy with This network meta-analysis of 54 studies, conducted in Asia, North America, and Europe, included patients randomly assigned to donepezil, memantine, donepezil–memantine, and placebo It considered both English and Chinese publications, which expanded the scope and made the conclusions more reliable than an analysis of English articles only Citation 13, Citation 14 In 2003, memantine was approved for the treatment of moderate to severe AD in the US and in Europe Approval for memantine permitted it to be used alone or in combination with ChEI While it is currently in use for the therapy of moderate to severe AD, other diseases and disorders are potential targets for therapy with The effectiveness of memantine hydrochloride (initiated at 5 mg once daily orally and increased weekly by 5 mg per day in divided doses to a dose of 20 mg per day (10 mg twice a day)) in moderate jamanetwork com journals jama fullarticle 198033--- sciencedirect com science article pii B978012815854800032X Memantine is available for the treatment of moderate to severe AD in Europe , but must be assessed by the National Institute of Clinical Excellence before it can become widely available in the UK, where some doctors are already prescribing it subject to funding limitations Seven people assigned memantine and three people assigned placebo did not complete 16 weeks of treatment or have neuropsychological assessments at T1 and T2 visits Additionally, one person in the memantine group was excluded from the outcome analysis because of medication compliance less than 80% onlinelibrary wiley com doi full 10 1002 ibra 12098Does memantine treat dementia? Sep 10, 2020 · Donepezil showed an advantage over memantine in mild-to-moderate AD, whereas memantine was more effective than donepezil in severe AD The combination therapy of memantine plus donepezil achieved better outcomes than placebo in the CGI The CGI scale combines the severity of illness, global improvement, and efficacy index People also askObjective We directly assessed the clinical trials' evidence for memantine's efficacy in mild Alzheimer disease (AD) Memantine is indicated in the United States and Europe for moderate to severe AD, which is diagnosed if a patient has a Mini-Mental State Examination (MMSE) score of less than 15 or less than 20, respectively Jun 6, 2023 · Memantine is a noncompetitive moderate-affinity strong voltage-dependent N-methyl-D-aspartate receptor antagonist It has been used to treat Alzheimer's disease (AD) since 1989 In 2018, it became the second most commonly used drug for the treatment of dementia in the world --- thelancet com journals laneur article PIIS1474442203004861 fulltextThis chapter describes the role of memantine in the treatment of Alzheimer's disease (AD) Among the approved medications for the treatment of AD, memantine is the only drug that acts on the glutamatergic system Moreover, it is a very well tolerated medication due to its blocking unblocking kinetics A closer look at the history of memantine

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